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KMID : 0363819940280030364
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Korean Journal of Nuclear Medicine
1994 Volume.28 No. 3 p.364 ~ p.370
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Synthesis of [^(51)Cr]Cr(m)-EDTA Complex and Measurement of Glomerular
Filtration Rate by Radioactivity Counting of Head and Neck Region
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양승대/Yang, Seung-Dae
임상무/전권수/서용섭/윤용기/박현/우광선/lim, Sang-Moo/Chun, Kwon-Soo/Suh, Yong-Sub/Yoon, Yong-Ki/Park, Hyun/Woo, Kwang-Sun
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Abstract
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The purpose of this study is to evaluate the clinical application of the no carrier added[51Cr] Cr( m )-EDTA complexes, produced at Korea Cancer Center Hospital. The[51Cr]Cr(m )-EDTA complexes, useful for measurement of GFR were prepared at room temperature in the presence of bicarbonate catalysts. The radiochemical purity of[5tCr]Cr( m )-EDTA was over 99 by paper electrophoresis.
The time activity curves were obtained by counting the blood samples from 5 volunteers and counting the head and neck regions with whole body counter after injection of the 51Cr-EDTA, respectively. After the nonlinear regression,, the area under curve was obtained. The plasma clearance of the 51Cr-EDTA was calculated with injected dose/AUC. The clearance rate calculated with the head and neck counting data was in good agreement with the result from the plasma sample radioactivity at 1-3 hrs after injection. From this result, the counting of head and neck region and the nonlinear regression by 2-compartment model could be applied for the measurement of the clearance rate.
Using MIRD system, the absorbed, radiation dose was calculated by residence time x S. The absorbed whole body radiation dose was negligibly small.
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